CRH_Server Help | click here |

› Use  CRH_Server  to analyze your own RH data on the current canine RH map and/or 
   to run comparative dog/human mapping analysis 

CRH_Server use and options :

Copy/paste the RH vector into the text area.
Use default values or select :

1 : the number of markers linked to be returned
2 : the CFA to be searched
3 : the nature of markers to be searched (microsatellites or genes or BACs markers ... can be selected)
4 : the analysis : 
        - "RH analysis" will return 2pt-linkage Radiation Hybrid results 
        - "Canine/Human comparative search" will return the canine chromosomal 
	   assignment AND the orthologous human location 
        - "RH analysis and comparative search" will return all results



Interpreting Results
 
	
Output displays for RH analysis.
1 : Hypertext links for marker(s) linked to the tested marker allow  
to obtain all corresponding PCR informations, map positions  
characteristics and references ; and OMIM link for gene based marker.

2 : The canine chromosomal assignement and coordinates (TSP_units)  
of the tested marker(s) with the chromosome figure.

3 : The LOD score and the two-point distance expressed in  
centiray5000 between the tested marker and linked marker(s).

4 : The retention level of the tested RH vector, and the number of  
ambigous RH scoring are systematically returned.

5 : A possibilty of a new RH analysis search is systematically  
proposed based on an enlarged RH data set daily updated.

		
 Output displays for comparative dog/human mapping analysis
1 : Hypertext links for marker(s) linked to the tested marker

2 : The canine chromosomal assignement and coordinates expressed in  
RH map units for the tested marker(s). Hyperlinks to the MapViewer  
Server canine database.and to the figure (pdf file) of the canine  
chromosome with the corresponding human chromosome segment(s).

3 : The human orthologue sequence coordinates (when known) with  
hyperlink that returns the 2 Mb human orthologous annotated sequence  
from the MapViewer Server human database.

4 : The possibilty to display the conserved dog/human synteny for  
either the complete dog chromosome or the complete hsa chromosome  
identified by the analysis is automatically available at the bottom of  
the web page.